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Research Paper on Atopic Dermatitis:

Mechanisms, and Treatments Abstract

아토피피부염(Atopic dermatitis, AD)은 만성 난치성 염증성 피부질환으로, 주로 가려움증과 피부발적, 태선화, 피부감염 등을 특징으로 합니다. 이 질환은 유전적인 요인과 후천적인 요인에 의해 발생하며, 그 원인은 매우 복잡합니다.

아토피 피부염(AD)은 만성적이고 비감염성 염증성 피부 질환으로, 지속적인 가려움증이 주요 특징입니다.

아토피 피부염은 만성적인 경과와 경제적 부담으로 인해 환자와 가족의 삶의 질을 저하시키며, 사회적 문제로 대두되고 있습니다.

Figure 4. Therapies based on the pathogenesis of atopic dermatitis. TSLP(Thymic stromal lymphopoietin), IL25 (Interleukin 25), IL33 (Interleukin 33), Th2 (T helper cells 2), IL4 (Interleukin 4), IL5 (Interleukin 5), IL13 (Interleukin 13), IL31 (Interleukin 31), Th1 (T helper cells 1), IL2(Interleukin 2), TNFα (Tumor necrosis factor alpha), INFγ (Interferon gamma), Th22 (T helper cells 22), IL22 (Interleukin 22), Th17 (T helper cells 17), IL17 (Interleukin 17).

Figure 1. Epigenetic regulations dependent on environmental factors.

Figure 2. Immunological aberrations of atopic dermatitis. PRR (Pattern recognition receptors), PAMP (Pathogen-associated molecular patterns), CLR (C lectin receptors), PGLYRP (peptidoglycan recognition proteins), NOD (Nucleotide-binding oligomerization domain), TLR (Toll-like receptors), IL6 (Interleukin 6), IL12 (Interleukin 12),TSLP(Thymic stromal lymphopoietin), IL25 (Interleukin 25), IL33 (Interleukin 33), Th2 (T helper cells 2), IL4 (Interleukin 4), IL5 (Interleukin 5), IL13 (Interleukin 13), IL31 (Interleukin 31), Th1 (T helper cells 1), IL2(Interleukin 2), TNFα (Tumor necrosis factor alpha), INFγ (Interferon gamma), Th22 (T helper cells 22), IL22 (Interleukin 22), Th17 (T helper cells 17), IL17 (Interleukin 17).

Figure 3. S. aureus virulence factors & atopic skin susceptibility factors. PSMα (Phenol-soluble modulins alpha), KC (Keratinocytes), IL-1α (Interleukin 1α), IL-36α (Interleukin 36α), Tγδ (Gamma delta T cells), ILC3 (Type 3 innate lymphoid cells), IL-17 (Interleukin 17), N (Neutrophils), Rec. TNF (receptors for Tumor necrosis factor), ClfA (Clumping factors A), ClfB (clumping factors B), fnBP (Fibronectin-binding protein), IsdA (Iron-regulated surface determinant A), SCFA, PAMP (Pathogen-associated molecular patterns), TLR2 (Toll-like receptor 2), Th2(T helper cells 2), IL-4 (Interleukin 4), IL-13 (Interleukin 13), AMP (Antimicrobial peptides), IL-31 (Interleukin 31), SEA (Staphylococcal enterotoxin A), SEB (Staphylococcal enterotoxin B), SEC (Staphylococcal enterotoxin C), TSST1 (toxic shock syndrome toxin 1), L (Lymphocytes), M (Macrophages).

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